RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
CAS: 199666-03-0
Molecular Formula: C17H15N3O6S2
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide - Names and Identifiers
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide - Physico-chemical Properties
| Molecular Formula | C17H15N3O6S2 |
| Molar Mass | 421.45 |
| Density | 1.471±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 185℃ |
| Boling Point | 627.4±65.0 °C(Predicted) |
| Solubility | DMSO: ≥15mg/mL |
| Appearance | Yellow solid |
| Color | faint yellow to yellow |
| pKa | 6.29±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In gerbils, a dose of 30 µmol/kg po (12.64 µg/kg Ro 61-8048, compound 16) leads to inhibition of the cerebral enzyme which peaked after 2h (∼85% inhibition) and persisted for up to 8 h. Ro 61-8048 (0.1-100 μM) strongly reduces QUIN neo-formation, suggesting that, in vitro, kynurenine hydroxylase activity is required for QUIN neosynthesis. |
| In vivo study | In gerbils and rat models, Ro 61-8048 (30 mg/kg, p.o.) induces inhibition of kynurenine 3-hydroxylase. PD 61-8048 (40 mg/kg, p.o.) reduced ischemic brain damage in models of focal or global cerebral ischemia. In a hamster model of paroxysmal dyskinesia, Ro 61-8048 (150 mg/kg I. p.) significantly reduced the severity of dyskinesia without significant side effects. In addition, the fetal inhibition of the kynurenine pathway by PD 61-8048 resulted in structural changes in the hippocampus of adult rat offspring. |
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.373 ml | 11.864 ml | 23.728 ml |
| 5 mM | 0.475 ml | 2.373 ml | 4.746 ml |
| 10 mM | 0.237 ml | 1.186 ml | 2.373 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.475 ml |
Last Update：2024-01-02 23:10:35
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide - Reference Information
| biological activity | Ro 61-8048 is a KMO inhibitor with an IC50 of 37 nM, ki was 4.8 nM. |
| Target | Value |
| KMO (Cell-free assay) | 4.8 nM(Ki) 37 nM |
Last Update：2024-04-10 22:29:15
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RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
4,4-二羟基-[1,1-联苯]-2-羧酸
FERRISPEC(R) PL BLACK IRON OXIDE
(S)-3-((叔丁氧羰基)氨基)-3-(3,4-二氯苯基)丙酸
2-呋喃硼酸甲基亚氨基二乙酸酯
4,4-二羟基-[1,1-联苯]-2-羧酸
FERRISPEC(R) PL BLACK IRON OXIDE
(S)-3-((叔丁氧羰基)氨基)-3-(3,4-二氯苯基)丙酸
2-呋喃硼酸甲基亚氨基二乙酸酯